{"id":3677,"date":"2021-11-17T17:57:00","date_gmt":"2021-11-17T09:57:00","guid":{"rendered":"http:\/\/www.genomeprecision.com\/?p=3677"},"modified":"2021-12-15T11:01:31","modified_gmt":"2021-12-15T03:01:31","slug":"%e5%96%9c%e8%ae%af-%e6%97%8c%e5%87%86%e5%8c%bb%e7%96%97idh1%e5%9f%ba%e5%9b%a0%e7%aa%81%e5%8f%98%e6%a3%80%e6%b5%8b%e8%af%95%e5%89%82%e7%9b%92%ef%bc%88%e8%8d%a7%e5%85%89pcr-%e6%af%9b%e7%bb%86%e7%ae%a1","status":"publish","type":"post","link":"http:\/\/www.genomeprecision.com\/2021\/11\/17\/%e5%96%9c%e8%ae%af-%e6%97%8c%e5%87%86%e5%8c%bb%e7%96%97idh1%e5%9f%ba%e5%9b%a0%e7%aa%81%e5%8f%98%e6%a3%80%e6%b5%8b%e8%af%95%e5%89%82%e7%9b%92%ef%bc%88%e8%8d%a7%e5%85%89pcr-%e6%af%9b%e7%bb%86%e7%ae%a1\/","title":{"rendered":"\u65cc\u51c6\u533b\u7597IDH1\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\u6b63\u5f0f\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02"},"content":{"rendered":"\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\"><section style=\"display: flex;justify-content: center;align-items: center;width: 100%;padding: 6px 24px;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"display: flex;justify-content: flex-start;align-items: center;flex-direction: column;width: 100%;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"display: flex;justify-content: flex-start;align-items: center;flex-direction: column;margin-bottom: -46px;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"display: flex;justify-content: center;align-items: center;justify-content: space-between;width: 100%;padding: 0px 24px;margin-bottom: -6px;z-index: 1;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"width: 5px;height: 21px;\" data-mid=\"\" mpa-from-tpl=\"t\"><\/section><section style=\"width: 5px;height: 21px;\" data-mid=\"\" mpa-from-tpl=\"t\"><\/section><\/section><section style=\"background: rgb(255, 216, 88);\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"height: 26px;background: rgb(238, 79, 31);padding: 0px 38px;transform: translate(-2px, -2px);\" data-mid=\"\" mpa-from-tpl=\"t\"><p style=\"font-size: 14px;font-family: PingFangSC-Semibold, &quot;PingFang SC&quot;;font-weight: bold;color: rgb(255, 255, 255);line-height: 26px;\" data-mid=\"\">\u559c\u62a5<span style=\"background-color: rgb(255, 255, 255);color: rgb(51, 51, 51);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;\"><\/span><\/p><\/section><\/section><\/section><section style=\"background: rgb(255, 216, 88);border-radius: 1px;border-width: 1px;border-style: solid;border-color: rgb(51, 51, 51);padding: 4px;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"background: rgb(255, 255, 255);border-radius: 1px;border-width: 1px;border-style: solid;border-color: rgb(51, 51, 51);padding: 54px 22px 22px;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"width: 100%;margin-top: 14px;\" data-mid=\"\" mpa-from-tpl=\"t\"><section style=\"font-size: 14px;font-family: PingFangSC-Semibold, &quot;PingFang SC&quot;;font-weight: bold;color: rgb(74, 72, 65);line-height: 24px;text-indent: 2em;\">2021\u5e7411\u6708\uff0c\u65cc\u51c6\u533b\u7597IDH1\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u8367\u5149PCR-\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u6d4b\u5e8f\u6cd5\uff09\uff08<span style=\"color: rgb(255, 76, 65);\"><strong>\u56fd\u68b0\u6ce8\u51c620213400928<\/strong><\/span>\uff09\u6b63\u5f0f\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02\uff0c\u8fd9\u662f\u56fd\u5185\u83b7\u6279\u7684\u9996\u4e2a\u57fa\u4e8eSanger\u6d4b\u5e8f\u5e73\u53f0\u7684IDH1\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\u3002Sanger\u6d4b\u5e8f\u662f\u76ee\u524d\u4e1a\u5185\u516c\u8ba4\u7684\u5206\u5b50\u7a81\u53d8\u68c0\u6d4b\u201c\u91d1\u6807\u51c6\u201d\uff0c\u65cc\u51c6\u533b\u7597\u4f9d\u6258Sanger\u6d4b\u5e8f\u5e73\u53f0\u6253\u9020\u7684IDH1\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\u80fd\u591f\u6700\u5927\u9650\u5ea6\u5730\u4fdd\u8bc1\u68c0\u6d4b\u7ed3\u679c\u7684\u51c6\u786e\u6027\u3002<span style=\"text-indent: 2em;\">\u8be5\u8bd5\u5242\u76d2\u5e94\u7528PCR-\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u6d4b\u5e8f\u6cd5\u5bf9\u6269\u589e\u540e\u7684PCR\u7247\u6bb5\u8fdb\u884c\u5206\u6790\uff0c\u53ef\u9274\u5b9a\u6837\u672c\u4e2d\u7684IDH1\u57fa\u56e0\u7b2c4\u5916\u663e\u5b50R132\u7a81\u53d8\uff0c\u5176\u68c0\u6d4b\u7ed3\u679c\u53ef\u4ee5\u4f5c\u4e3a\u4e34\u5e8a\u8f85\u52a9\u8bca\u65ad\uff0c\u4e3a\u4e34\u5e8a\u533b\u751f\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u63d0\u4f9b\u53c2\u8003\u3002<\/span><\/section><section style=\"font-size: 14px;font-family: PingFangSC-Semibold, &quot;PingFang SC&quot;;font-weight: bold;color: rgb(74, 72, 65);line-height: 24px;text-indent: 2em;\"><span style=\"text-indent: 2em;\"><\/span><span style=\"text-indent: 2em;\">\u76ee\u524d\uff0c\u65cc\u51c6\u533b\u7597\u5171\u67097\u5f20\u5206\u5b50\u8bca\u65ad\u4e09\u7c7b\u6ce8\u518c\u8bc1\uff0c\u57282024\u5e74\u5e95\u4e4b\u524d\u4e0a\u8ff0\u6ce8\u518c\u8bc1\u6570\u91cf\u5c06\u8d85\u8fc730\u5f20\uff0cIDH<\/span><span style=\"text-indent: 2em;\">1<\/span><span style=\"text-indent: 2em;\">\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2<\/span><span style=\"text-indent: 2em;\">\u7684\u83b7\u8bc1<\/span><span style=\"text-indent: 2em;\">\u8fdb\u4e00\u6b65\u58ee\u5927\u4e86\u65cc\u51c6\u533b\u7597\u7cbe\u51c6\u8bca\u65ad\u7cfb\u5217\u4ea7\u54c1\u7fa4\uff0c\u540c\u65f6\uff0c\u4e5f\u6807\u5fd7\u7740\u65cc\u51c6\u533b\u7597\u6df1\u8015\u5206\u5b50\u8bca\u65ad\u5e03\u5c40\u7684\u9636\u6bb5\u6027\u80dc\u5229\uff0c<\/span><span style=\"text-indent: 2em;\">\u4e3a\u65cc\u51c6\u533b\u7597\u5f15\u9886\u7cbe\u51c6\u533b\u5b66\u6253\u4e0b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002\u201c\u7cbe\u51c6\u4eba\u201d\u59cb\u7ec8\u4e0d\u5fd8\u521d\u5fc3\uff0c\u7825\u783a\u524d\u884c\uff0c\u76f8\u4fe1\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u65cc\u51c6\u4f1a\u6709\u66f4\u591a\u7684\u4ea7\u54c1\u8d70\u5411\u4e34\u5e8a\uff0c\u670d\u52a1\u793e\u4f1a\u3002<\/span><\/section><\/section><\/section><\/section><\/section><\/section><\/section>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong><span class=\"has-inline-color has-colibri-color-1-color\">IDH1\u57fa\u56e0<\/span><\/strong><\/p>\n\n\n\n<p>       IDH\uff08Isocitrate Dehydrogenase)\u57fa\u56e0\u5bb6\u65cf\u7f16\u7801\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176\uff0c\u662f\u4e09\u7fa7\u9178\u5faa\u73af\u4e2d\u7684\u4e00\u4e2a\u5173\u952e\u6027\u9650\u901f\u9176\uff0c\u4e3a\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u63d0\u4f9b\u80fd\u91cf\u548c\u751f\u7269\u5408\u6210\u7684\u524d\u4f53\u7269\u8d28\u3002IDH\u57fa\u56e0\u5bb6\u65cf\u6709\u4e09\u4e2a\u6210\u5458\uff0c\u5206\u522b\u662fIDH1\uff0cIDH2\u548cIDH3\u3002\u591a\u79cd\u6076\u6027\u80bf\u7624\u4e2d\u5747\u5b58\u5728IDH\u7a81\u53d8\uff0c\u5305\u62ec\u8111\u80f6\u8d28\u7624\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001\u80c6\u7ba1\u764c\u3001\u8840\u7ba1\u514d\u75ab\u6027T\u6dcb\u5df4\u7ec6\u80de\u764c\u3001\u6dcb\u5df4\u7ec6\u80de\u764c\u7b49\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.genomeprecision.com\/wp-content\/uploads\/2021\/12\/NMPA_IDH1\u57fa\u56e0.webp\" alt=\"\" class=\"wp-image-3685\" width=\"1080\" height=\"459\"\/><\/figure><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong><span class=\"has-inline-color has-colibri-color-1-color\">IDH1\u4e0e\u8111\u80f6\u8d28\u7624<\/span><\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size\">       \u8111\u80f6\u8d28\u7624\u8d77\u6e90\u4e8e\u8111\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\uff0c\u662f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6700\u5e38\u89c1\u7684\u539f\u53d1\u6027\u9885\u5185\u80bf\u7624\uff0c\u5360\u6240\u6709\u539f\u53d1\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624\u768427%\uff0c\u5360\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u768480%\u3002\u8111\u80f6\u8d28\u7624\u6076\u6027\u7a0b\u5ea6\u9ad8\u3001\u751f\u957f\u5feb\u3001\u75c5\u7a0b\u77ed\u3001\u672f\u540e\u6613\u590d\u53d1\u4e14\u9ad8\u81f4\u6b8b\uff0c\u88ab\u8ba4\u4e3a\u662f\u795e\u7ecf\u5916\u79d1\u6cbb\u7597\u4e2d\u6700\u68d8\u624b\u7684\u96be\u6cbb\u6027\u80bf\u7624\u4e4b\u4e00\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.genomeprecision.com\/wp-content\/uploads\/2021\/12\/IDH1\u4e0e\u8111\u80f6\u8d28\u76241.webp\" alt=\"\" class=\"wp-image-3683\" width=\"1031\" height=\"506\"\/><\/figure><\/div>\n\n\n\n<p>       \u76ee\u524d\u9274\u5b9a\u8111\u80f6\u8d28\u7624\u7684\u4e3b\u8981\u5206\u5b50\u75c5\u7406\u6807\u5fd7\u7269\u5305\u62ec\uff1aIDH\u7a81\u53d8\uff0c\u67d3\u8272\u4f531p\/19q\u8054\u5408\u7f3a\u5931\u72b6\u6001\u3001O<sup>6<\/sup>-\u7532\u57fa\u9e1f\u560c\u5464-DNA\u7532\u57fa\u8f6c\u79fb\u9176\u542f\u52a8\u5b50\u533a\u7532\u57fa\u5316\u7b49\uff0c\u8fd9\u4e9b\u5206\u5b50\u6807\u5fd7\u7269\u5bf9\u8111\u80f6\u8d28\u7624\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u53ca\u4e34\u5e8a\u9884\u540e\u5224\u65ad\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u65cc\u51c6\u533b\u7597\u53ef\u68c0\u6d4b\u5305\u62ecIDH1\/2\u30011p19q\u3001TERT\u3001MGMT\u3001TP53\u57fa\u56e0\u7b49\u5728\u5185\u7684\u591a\u79cd\u8111\u80f6\u8d28\u7624\u5206\u5b50\u75c5\u7406\u6807\u5fd7\u7269\uff0c\u4e3a\u8111\u80f6\u8d28\u7624\u7684\u8bca\u65ad\u548c\u5206\u578b\u63d0\u4f9b\u591a\u79cd\u601d\u8def\uff0c\u540c\u65f6\u4e5f\u6781\u5927\u5730\u63a8\u52a8\u4e86\u8111\u80f6\u8d28\u7624\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.genomeprecision.com\/wp-content\/uploads\/2021\/12\/IDH1\u4e0e\u8111\u80f6\u8d28\u76242.webp\" alt=\"\" class=\"wp-image-3684\" width=\"1080\" height=\"543\"\/><\/figure><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong><span class=\"has-inline-color has-colibri-color-1-color\">IDH1\u4e0e\u767d\u8840\u75c5<\/span><\/strong><\/p>\n\n\n\n<p>       \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u662f\u6700\u5e38\u89c1\u7684\u767d\u8840\u75c5\u7c7b\u578b\u4e4b\u4e00\uff0c\u5176\u4e3b\u8981\u7279\u5f81\u4e3a\u9aa8\u9ad3\u4e0e\u5916\u5468\u8840\u4e2d\u539f\u59cb\u7956\u7ec6\u80de\u548c\u5e7c\u7a1a\u9ad3\u7cfb\u7ec6\u80de\u5206\u5316\u963b\u6ede\uff0c\u5bfc\u81f4\u5904\u4e8e\u4e0d\u540c\u5206\u5316\u9636\u6bb5\u7684\u539f\u59cb\u9ad3\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u5e76\u79ef\u7d2f\uff0c\u800c\u5177\u6709\u6b63\u5e38\u529f\u80fd\u7684\u7ea2\u7ec6\u80de\u3001\u8840\u5c0f\u677f\u548c\u767d\u7ec6\u80de\u7684\u751f\u6210\u6025\u5267\u51cf\u5c11\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.genomeprecision.com\/wp-content\/uploads\/2021\/12\/IDH1\u4e0e\u767d\u8840\u75c5.webp\" alt=\"\" class=\"wp-image-3681\" width=\"1063\" height=\"452\"\/><\/figure><\/div>\n\n\n\n<p>       IDH1\u7a81\u53d8\u662fAML\u5e38\u89c1\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u540c\u65f6\u4e5f\u662fAML\u60a3\u8005\u9884\u540e\u4e0d\u826f\u7684\u5206\u5b50\u6807\u5fd7\uff0c\u7a81\u53d8\u4e9a\u578b\u5305\u62ec\u591a\u79cd\uff0c\u5305\u62ecIDH1 R132H\u3001IDH1 R132C\u3001IDH1 R132S\u3001IDH1 R132G\u3001IDH1 R132L\u3001IDH1 R132P\u7b49\u3002IDH1\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\u53ef\u9274\u5b9a\u77f3\u8721\u5207\u7247\u6837\u672c\u4e2d\u7684IDH1\u57fa\u56e0\u7b2c4\u5916\u663e\u5b50R132\u7a81\u53d8\uff0c\u5305\u62ec\u4e0a\u8ff0\u76ee\u524d\u5df2\u77e5\u7684\u7a81\u53d8\u4e9a\u578b\uff0cIDH1\u7a81\u53d8\u7684AML\u60a3\u8005\u53ef\u5e94\u7528\u9776\u5411\u836f\u7269\u6cbb\u7597\uff0c\u4ece\u800c\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u5b58\u7387\u3002IDH1\u57fa\u56e0\u7a81\u53d8\u7684\u68c0\u6d4b\u4e3aAML\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong><span class=\"has-inline-color 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